Applied and didactic activities take place in the Spirito Santo complex (DiARC | Dipartimento di Architettura) whose access is from via Toledo 402 or from via Forno Vecchio 36. The venue is in the historic center of Naples, just a few steps away from Metro Line 1 station (Dante, Toledo), Metro Line 2 station (Montesanto) and from the Cumana and Funiculare railway station.

Palazzo Orsini di Gravina is an elegant example of Renaissance architecture of Tuscan and Roman derivation in Naples. Since 1936 it has been the headquarters of the Faculty of Architecture of the University Federico II. Today, the building houses Roberto Pane Library and Area Architettura Library and also hosts final degree’s sessions.